|Function||4-hydroxybenzoate polyprenyl transferase|
|Domain Trusted Cutoff||275.45|
|Domain Noise Cutoff||160.95|
|Mainrole Category||Biosynthesis of cofactors, prosthetic groups, and carriers|
|Subrole Category||Menaquinone and ubiquinone|
|Gene Ontology Term||GO:0006744: ubiquinone biosynthetic process biological_process|
| ||GO:0008412: 4-hydroxybenzoate octaprenyltransferase activity molecular_function|
|Entry Date||Mar 20 2002 2:21PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity.
A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members.|
|References||DR EXPERIMENTAL; SP:P32378; p-hydroxybenzoate:polyprenyl transferase; Saccharomyces cerevisiae
DR EXPERIMENTAL; SP:P26601; 4-hydroxybenzoate octaprenyltransferase; Escherichia coli; ubiA
DR EXPERIMENTAL; SP|O52366; 4-hydroxybenzoate octaprenyltransferase; Providencia stuartii; aarE
RT Phenotypes of fission yeast defective in ubiquinone production due to disruption of the gene for p-hydroxybenzoate polyprenyl diphosphate transferase.
RA Uchida N, Suzuki K, Saiki R, Kainou T, Tanaka K, Matsuda H, Kawamukai M.
RL J Bacteriol 2000 Dec;182(24):6933-9
DR HAMAP; MF_01635; 160 of 167|
|Genome Property||GenProp0136: ubiquinone biosynthesis from chorismate, aerobic (HMM)|
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