| Accession | TIGR01481 |
| Name | ccpA |
| Function | catabolite control protein A |
| Gene Symbol | ccpA |
| Trusted Cutoff | 442.35 |
| Domain Trusted Cutoff | 442.35 |
| Noise Cutoff | 328.65 |
| Domain Noise Cutoff | 328.65 |
| Isology Type | equivalog |
| HMM Length | 330 |
| Mainrole Category | Regulatory functions |
| Subrole Category | DNA interactions |
| Gene Ontology Term | GO:0003677: DNA binding molecular_function |
| | GO:0005975: carbohydrate metabolic process biological_process |
| | GO:0006355: regulation of transcription, DNA-dependent biological_process |
| | GO:0016563: transcription activator activity molecular_function |
| | GO:0016564: transcription repressor activity molecular_function |
| Author | Beanan M |
| Entry Date | Apr 1 2002 11:21AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Catabolite control protein A is a LacI family global transcriptional regulator found in Gram-positive bacteria. CcpA is involved in repressing carbohydrate utilization genes [ex: alpha-amylase (amyE), acetyl-coenzyme A synthase (acsA)] and in activating genes involved in transporting excess carbon from the cell [ex: acetate kinase (ackA), alpha-acetolactate synthase (alsS)]. Additionally, disruption of CcpA in Bacillus megaterium, Staphylococcus xylosus, Lactobacillus casei and Lactocacillus pentosus also decreases growth rate, which suggests CcpA is involved in the regulation of other metabolic pathways. |
| References | RN [1]
RM PMID:10094627
RT Transcriptional activation of the glycolytic las operon and catabolite repression of the gal operon in Lactococcus lactis are mediated by the catabolite control protein CcpA.
RA Luesink EJ, van Herpen RE, Grossiord BP, Kuipers OP, de Vos WM
RL Mol Microbiol. 1998 Nov;30(4):789-98. |
