HMM Summary Page: TIGR01497

FunctionK+-transporting ATPase, B subunit
Gene SymbolkdpB
Trusted Cutoff527.90
Domain Trusted Cutoff527.90
Noise Cutoff398.75
Domain Noise Cutoff398.75
Isology Typeequivalog
EC Number3.6.3.12
HMM Length675
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0006813: potassium ion transport biological_process
GO:0008556: potassium-transporting ATPase activity molecular_function
GO:0031004: potassium ion-transporting ATPase complex cellular_component
AuthorSelengut J, Beanan M
Entry DateMay 6 2002 11:11AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit[1]. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit [2], while KdpF serves to stabilize the complex [3]. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB) [4]. Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics [1]. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR.
ReferencesRN [1] RM PMID: 1970651 RT The bacterial Kdp K(+)-ATPase and its relation to other transport ATPases, such as the Na+/K(+)- and Ca2(+)-ATPases in higher organisms. RA Epstein W, Walderhaug MO, Polarek JW, Hesse JE, Dorus E, Daniel JM. RL Philos Trans R Soc Lond B Biol Sci 1990 Jan 30;326(1236):479-86; discussion 486-7 RN [2] RM PMID: 9858692 RT Assembly of the Kdp complex, the multi-subunit K+-transport ATPase of Escherichia coli. RA Gassel M, Siebers A, Epstein W, Altendorf K. RL Biochim Biophys Acta 1998 Dec 9;1415(1):77-84 RN [3] RM PMID: 10608856 RT The KdpF subunit is part of the K(+)-translocating Kdp complex of Escherichia coli and is responsible for stabilization of the complex in vitro. RA Gassel M, Mollenkamp T, Puppe W, Altendorf K. RL J Biol Chem. 1999 Dec 31;274(53):37901-7. RN [4] RM PMID:9419228 RT Evolution of Substrate Specificities in the P-type ATPase Superfamily. RA Axelsen KB, Palmgren, MG. RL J Mol Evol. 1998 Jan; 46(1): 84-101. DR HAMAP; MF_00285; 77 of 78
Genome PropertyGenProp0172: Potassium-transporting ATPase KdpFABC (HMM)