HMM Summary Page: TIGR01504

Functionglyoxylate carboligase
Gene Symbolgcl
Trusted Cutoff711.20
Domain Trusted Cutoff711.20
Noise Cutoff589.15
Domain Noise Cutoff589.15
Isology Typeequivalog
EC Number4.1.1.47
HMM Length589
AuthorHaft DH
Entry DateMay 10 2002 3:14PM
Last ModifiedFeb 14 2011 3:27PM
CommentGlyoxylate carboligase, also called tartronate-semialdehyde synthase, releases CO2 while synthesizing a single molecule of tartronate semialdehyde from two molecules of glyoxylate. It is a thiamine pyrophosphate-dependent enzyme, closely related in sequence to the large subunit of acetolactate synthase. In the D-glycerate pathway, part of allantoin degradation in the Enterobacteriaceae, tartronate semialdehyde is converted to D-glycerate and then 3-phosphoglycerate, a product of glycolysis and entry point in the general metabolism.
ReferencesDR EXPERIMENTAL; SP|P30146; Escherichia coli DR OUTGROUP; SP|P42463; acetolactate synthase large subunit
Genome PropertyGenProp0689: glyoxalate conversion to phosphoglycerate (HMM)