| Accession | TIGR01507 |
| Name | hopene_cyclase |
| Function | squalene-hopene cyclase |
| Gene Symbol | shc |
| Trusted Cutoff | 431.10 |
| Domain Trusted Cutoff | 431.10 |
| Noise Cutoff | 386.85 |
| Domain Noise Cutoff | 386.85 |
| Isology Type | equivalog |
| EC Number | 5.4.99.17 |
| HMM Length | 640 |
| Mainrole Category | Fatty acid and phospholipid metabolism |
| Subrole Category | Other |
| Gene Ontology Term | GO:0019746: hopanoid biosynthetic process biological_process |
| | GO:0051007: squalene-hopene cyclase activity molecular_function |
| Author | Brinkac L |
| Entry Date | May 15 2002 3:01PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products [1,2]. |
| References | RN [1]
RM 97442532
RT Structure and function of a squalene cyclase
RA Wendt KU, Lenhart A, Schulz GE.
RL Science 277:1811-1815(1997)
RN [2]
RM PMID: 12120044
RT Squalene-hopene cyclase: catalytic mechanism and substrate recognition.
RA Hoshino, T. and Sato, T.
RL Chem. Commun. (2002) 291-301.
DR PFAM; PF00432; Prenyltransferase/squalene oxidase repeat
DR PROSITE; PS01074; Terpene Synthases
DR EXPERIMENTAL; GP|3164082; Methylococcus capsulatus; heterologous expression in E.coli with in vitro activity of the recombinant cyclase demonstrated using crude cell-free lysate or solubilized membrane preparation
DR EXPERIMENTAL; GP|2970047; Alicyclobacillus acidocaldarius; heterologous expression in E.coli with site-directed mutagenesis experimentation determining active site residues.
DR HOMOLOGY; SP|P73914; Synechocystis sp.; homology based methodology and phylogenetic relationship. conservation of active site residues and structural motifs.
DR OUTGROUP; GP|1098635; Rattus norvegicus; Oxidosqualene Cyclase |
| Genome Property | GenProp0761: hopanoid lipid biosynthesis (HMM) |
