|Domain Trusted Cutoff||103.30|
|Domain Noise Cutoff||72.75|
|Mainrole Category||Biosynthesis of cofactors, prosthetic groups, and carriers|
|Subrole Category||Pantothenate and coenzyme A|
|Gene Ontology Term||GO:0004595: pantetheine-phosphate adenylyltransferase activity molecular_function|
| ||GO:0015937: coenzyme A biosynthetic process biological_process|
|Entry Date||May 16 2002 4:24PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This HMM describes pantetheine-phosphate adenylyltransferase, the penultimate enzyme of coenzyme A (CoA) biosynthesis in bacteria. It does not show any strong homology to eukaryotic enzymes of coenzyme A biosynthesis. This protein was previously designated KdtB and postulated (because of cytidyltransferase homology and proximity to kdtA) to be an enzyme of LPS biosynthesis, a cytidyltransferase for 3-deoxy-D-manno-2-octulosonic acid. However, no activity toward that compound was found with either CTP or ATP. The phylogenetic distribution of this enzyme is more consistent with coenzyme A biosynthesis than with LPS biosynthesis.|
RT Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli.
RA Geerlof A, Lewendon A, Shaw WV.
RL J Biol Chem 1999 Sep 17;274(38):27105-11
DR HAMAP; MF_00151; 431 of 437|
|Genome Property||GenProp0171: coenzyme A biosynthesis from pantothenate (HMM)|
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