Accession | TIGR01512 |
Name | ATPase-IB2_Cd |
Function | cadmium-translocating P-type ATPase |
Gene Symbol | cadA |
Trusted Cutoff | 313.50 |
Domain Trusted Cutoff | 313.50 |
Noise Cutoff | 304.30 |
Domain Noise Cutoff | 304.30 |
Isology Type | equivalog |
EC Number | 3.6.3.3 |
HMM Length | 494 |
Mainrole Category | Transport and binding proteins |
Subrole Category | Cations and iron carrying compounds |
Gene Ontology Term | GO:0015434: cadmium-transporting ATPase activity molecular_function |
| GO:0015691: cadmium ion transport biological_process |
Author | Selengut J |
Entry Date | May 20 2002 12:25PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants.
Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803.
The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species [1]. This HMM and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2.
Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). |
References | RN [1]
RM PMID:9419228
RT Evolution of Substrate Specificities in the P-type ATPase Superfamily.
RA Axelsen KB, Palmgren, MG.
RL J Mol Evol. 1998 Jan; 46(1): 84-101. |