| Accession | TIGR01514 |
| Name | NAPRTase |
| Function | nicotinate phosphoribosyltransferase |
| Gene Symbol | pncB |
| Trusted Cutoff | 269.55 |
| Domain Trusted Cutoff | 269.55 |
| Noise Cutoff | 170.90 |
| Domain Noise Cutoff | 170.90 |
| Isology Type | equivalog |
| EC Number | 2.4.2.11 |
| HMM Length | 399 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Pyridine nucleotides |
| Gene Ontology Term | GO:0004516: nicotinate phosphoribosyltransferase activity molecular_function |
| | GO:0019358: nicotinate nucleotide salvage biological_process |
| Author | Haft DH |
| Entry Date | May 20 2002 2:12PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). |
| References | DR EXPERIMENTAL; SP:P18133; Escherichia coli
DR EXPERIMENTAL; SP|P22253; Salmonella typhimurium
DR HAMAP; MF_00570; 81 of 81 |
