|Function||death-on-curing family protein|
|Domain Trusted Cutoff||38.65|
|Domain Noise Cutoff||38.30|
|Mainrole Category||Unknown function|
|Entry Date||Jun 13 2002 12:08PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||The characterized member of this family is the death-on-curing (DOC) protein of phage P1. It is part of a two protein operon with prevents-host-death (phd) that forms an addiction module. DOC lacks homology to analogous addiction module post-segregational killing proteins involved in plasmid maintenance. These modules work as a combination of a long lived poison (e.g. this protein) and a more abundant but shorter lived antidote.
Members of this family have a well-conserved central motif HxFx[ND][AG]NKR.
A similar region, with K replaced by G, is found in the huntingtin interacting protein (HYPE) family.|
RT Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained.
RA Lehnherr H, Maguin E, Jafri S, Yarmolinsky MB.
RL J Mol Biol 1993 Oct 5;233(3):414-28
DR EXPERIMENTAL; SP:Q06259; Bacteriophage P1|
|Genome Property||GenProp0321: addiction modules (HMM)|
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