HMM Summary Page: TIGR01562

Functionformate dehydrogenase accessory protein FdhE
Gene SymbolfdhE
Trusted Cutoff187.65
Domain Trusted Cutoff187.65
Noise Cutoff54.80
Domain Noise Cutoff54.80
Isology Typeequivalog
HMM Length305
AuthorSelengut J
Entry DateJun 24 2002 3:35PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes an accessory protein required for the assembly of formate dehydrogenase of certain proteobacteria although not present in the final complex [1]. The exact nature of the function of FdhE in the assembly of the complex is unknown, but considering the presence of selenocysteine, molybdopterin, iron-sulfur clusters and cytochrome b556, it is likely to have something to do with the insertion of cofactors. The only sequence scoring between trusted and noise is that from Aquifex aeolicus, which shows certain structural differences from the proteobacterial forms in the alignment. However it is notable that A. aeolicus also has a sequence scoring above trusted to the alpha subunit of formate dehydrogenase (TIGR01553).
ReferencesRN [1] RM PMID: 2170340 RT Identification and expression of the Escherichia coli fdhD and fdhE genes, which are involved in the formation of respiratory formate dehydrogenase. RA Schlindwein C, Giordano G, Santini CL, Mandrand MA. RL J Bacteriol 1990 Oct;172(10):6112-21. DR HAMAP; MF_00611; 50 of 52