HMM Summary Page: TIGR01580

AccessionTIGR01580
NamenarG
Functionnitrate reductase, alpha subunit
Trusted Cutoff1084.15
Domain Trusted Cutoff1084.15
Noise Cutoff600.95
Domain Noise Cutoff600.95
Isology Typeequivalog
EC Number1.7.99.4
HMM Length1235
Mainrole CategoryEnergy metabolism
Subrole CategoryAnaerobic
Gene Ontology TermGO:0008940: nitrate reductase activity molecular_function
GO:0008940: nitrate reductase activity molecular_function
GO:0008940: nitrate reductase activity molecular_function
GO:0009061: anaerobic respiration biological_process
GO:0009061: anaerobic respiration biological_process
GO:0009061: anaerobic respiration biological_process
GO:0009325: nitrate reductase complex cellular_component
GO:0009325: nitrate reductase complex cellular_component
GO:0009325: nitrate reductase complex cellular_component
AuthorDaugherty S
Entry DateJul 9 2002 3:25PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Nitrate reductase enzyme complex allows bacteria to use nitrate as an electron acceptor during anaerobic growth. The enzyme complex consists of a tetramer that has an alpha, beta and 2 gamma subunits. The alpha and beta subunits have catalytic activity and the gamma subunits attach the enzyme to the membrane and is a b-type cytochrome that receives electrons from the quinone pool and transfers them to the beta subunit. This model is specific for the alpha subunit for nitrate reductase I (narG) and nitrate reductase II (narZ) for gram positive and gram negative bacteria.A few thermophiles and archaea also match the model The seed members used to make the model include Nitrate reductases from Pseudomonas fluorescens (GP:11344601), E.coli (SP:P09152) and B.subtilis (SP:P42175). All seed members are experimentally characterized. Some unpublished nitrate reductases, that are shorter sequences, and probably fragments fall in between the noise and trusted cutoffs. Pfam models PF00384 (Molybdopterin oxidoreductase) and PF01568(Molydopterin dinucleotide binding domain) will also match the nitrate reductase, alpha subunit.
ReferencesRN [1] RM PMID:2233673 RT Nitrate reductases of Escherichia coli: sequence of the second nitrate reductase and comparison with that encoded by the narGHJI operon RA Blasco F, Iobbi C, Ratouchniak J, Bonnefoy V, Chippaux M RL Mol Gen Genet 1990 Jun;222(1):104-11 RN [2] RM PMID:2674654 RT Nitrate reductase of Escherichia coli: completion of the nucleotide sequence of the nar operon and reassessment of the role of the alpha and beta subunits in iron binding and electron transfer. RA Blasco F, Iobbi C, Giordano G, Chippaux M, Bonnefoy V. RL Mol Gen Genet 1989 Aug;218(2):249-56
Genome PropertyGenProp0636: respiratory nitrate reductase (HMM)
GenProp0636: respiratory nitrate reductase (HMM)
GenProp0636: respiratory nitrate reductase (HMM)