HMM Summary Page: TIGR01614

Functionpectinesterase inhibitor domain
Trusted Cutoff35.95
Domain Trusted Cutoff35.95
Noise Cutoff32.40
Domain Noise Cutoff32.40
Isology Typedomain
HMM Length178
AuthorHaft DH, Segal N
Entry DateJul 31 2002 2:02PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a plant domain of about 200 amino acids, characterized by four conserved Cys residues, shown in a pectinesterase inhibitor from Kiwi to form two disulfide bonds: first to second and third to fourth. Roughly half the members of this family have the region described by this HMM followed immediately by a pectinesterase domain, PF01095. This suggests that the pairing of the enzymatic domain and its inhibitor reflects a conserved regulatory mechanism for this enzyme family.
ReferencesDR EXPERIMENTAL; SP:P83326; pectin methylesterase inhibitor; kiwi RM 10880981 RT Kiwi protein inhibitor of pectin methylesterase amino-acid sequence and structural importance of two disulfide bridges. RA Camardella L, Carratore V, Ciardiello MA, Servillo L, Balestrieri C, Giovane A. RL Eur J Biochem 2000 Jul;267(14):4561-5