|Function||pectinesterase inhibitor domain|
|Domain Trusted Cutoff||35.95|
|Domain Noise Cutoff||32.40|
|Author||Haft DH, Segal N|
|Entry Date||Jul 31 2002 2:02PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This HMM describes a plant domain of about 200 amino acids, characterized by four conserved Cys residues, shown in a pectinesterase inhibitor from Kiwi to form two disulfide bonds: first to second and third to fourth. Roughly half the members of this family have the region described by this HMM followed immediately by a pectinesterase domain, PF01095. This suggests that the pairing of the enzymatic domain and its inhibitor reflects a conserved regulatory mechanism for this enzyme family.|
|References||DR EXPERIMENTAL; SP:P83326; pectin methylesterase inhibitor; kiwi
RT Kiwi protein inhibitor of pectin methylesterase amino-acid sequence and structural importance of two disulfide bridges.
RA Camardella L, Carratore V, Ciardiello MA, Servillo L, Balestrieri C, Giovane A.
RL Eur J Biochem 2000 Jul;267(14):4561-5|
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