HMM Summary Page: TIGR01622
Accession | TIGR01622 |
Name | SF-CC1 |
Function | splicing factor, CC1-like family |
Trusted Cutoff | 231.65 |
Domain Trusted Cutoff | 231.65 |
Noise Cutoff | 167.00 |
Domain Noise Cutoff | 167.00 |
Isology Type | subfamily |
HMM Length | 500 |
Gene Ontology Term | GO:0008380: RNA splicing biological_process |
Author | Selengut J |
Entry Date | Aug 8 2002 12:35PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: PF00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR [4] and was included in the seed. |
References | RN [1] RM PMID: 9578630 RT Repeat-induced point mutations in Pad-1, a putative RNA splicing factor from Neurospora crassa, confer dominant lethal effects on ascus development. RA Kuldau GA, Raju NB, Glass NL. RL Fungal Genet Biol 1998 Mar;23(2):169-80 RN [2] RM PMID: 11704680 RT Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors. RA Jung DJ, Na SY, Na DS, Lee JW. RL J Biol Chem 2002 Jan 11;277(2):1229-34 RN [3] RM PMID: 8227358 RT Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma. RA Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM. RL J Clin Invest 1993 Nov;92(5):2419-26 RN [4] RL TIGR, unpublished data |