| Accession | TIGR01683 |
| Name | thiS |
| Function | thiamine biosynthesis protein ThiS |
| Gene Symbol | thiS |
| Trusted Cutoff | 37.45 |
| Domain Trusted Cutoff | 37.45 |
| Noise Cutoff | 29.40 |
| Domain Noise Cutoff | 29.40 |
| Isology Type | equivalog |
| HMM Length | 64 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Thiamine |
| Gene Ontology Term | GO:0003824: catalytic activity molecular_function |
| | GO:0009228: thiamine biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Sep 19 2002 3:21PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents ThiS, a small thiamine-biosynthesis protein related to MoaD, a molybdenum cofactor biosynthesis protein. Both proteins are involved in sulfur transfer. ThiS has a conserved Gly-Gly C-terminus that is modified, in reactions requiring ThiI, ThiF, IscS, and a sulfur atom from Cys, into the thiocarboxylate that provides the sulfur for thiazole biosynthesis. |
| References | RM 10781607
RT The iscS gene in Escherichia coli is required for the biosynthesis of 4-thiouridine, thiamin, and NAD.
RA Lauhon CT, Kambampati R.
RL J Biol Chem. 2000 Jun 30;275(26):20096-103.
DR HAMAP; MF_00443; 1 of 268 |
| Genome Property | GenProp0250: thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly (HMM) |
