HMM Summary Page: TIGR01734

FunctionD-alanine--poly(phosphoribitol) ligase, subunit 1
Gene SymboldltA
Trusted Cutoff559.85
Domain Trusted Cutoff559.85
Noise Cutoff487.60
Domain Noise Cutoff487.60
Isology Typeequivalog
EC Number6.1.1.13
HMM Length504
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0019350: teichoic acid biosynthetic process biological_process
GO:0047473: D-alanine-poly(phosphoribitol) ligase activity molecular_function
AuthorSelengut J
Entry DateNov 1 2002 4:58PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the enzyme (also called D-alanine-D-alanyl carrier protein ligase) which activates D-alanine as an adenylate via the reaction D-ala + ATP -> D-ala-AMP + PPi, and further catalyzes the condensation of the amino acid adenylate with the D-alanyl carrier protein (D-ala-ACP). The D-alanine is then further transferred to teichoic acid in the biosynthesis of lipoteichoic acid (LTA) and wall teichoic acid (WTA) in gram positive bacteria, both polysacchatides [1].
ReferencesRN [1] RM PMID: 7797557 RT Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation. RA Perego M, Glaser P, Minutello A, Strauch MA, Leopold K, Fischer W. RL J Biol Chem 1995 Jun 30;270(26):15598-606 DR HAMAP; MF_00593; 53 of 53
Genome PropertyGenProp0958: D-alanyl-lipoteichoic acid biosynthesis (HMM)