HMM Summary Page: TIGR01749

Functionbeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA
Gene SymbolfabA
Trusted Cutoff238.15
Domain Trusted Cutoff238.15
Noise Cutoff160.10
Domain Noise Cutoff160.10
Isology Typeequivalog
EC Number4.2.1.59
HMM Length169
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryBiosynthesis
AuthorHaft DH
Entry DateNov 20 2002 4:09PM
Last ModifiedDec 12 2011 10:26PM
CommentThis enzyme, FabA, shows overlapping substrate specificity with FabZ with regard to chain length in fatty acid biosynthesis. It is commonly designated 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC as if it were specific for that chain length, but its specificity is broader; it is active even in the initiation of fatty acid biosynthesis. This enzyme can also isomerize trans-2-decenoyl-ACP to cis-3-decenoyl-ACP to bypass reduction by FabI and instead allow biosynthesis of unsaturated fatty acids. FabA cannot elongate unsaturated fatty acids.
ReferencesRN [1] RM 8910376 RT Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis. RA Heath RJ, Rock CO. RL J Biol Chem 1996 Nov 1;271(44):27795-801 RN [2] RM 9286984 RT Fatty acid biosynthesis in Pseudomonas aeruginosa: cloning and characterization of the fabAB operon encoding beta-hydroxyacyl-acyl carrier protein dehydratase (FabA) and beta-ketoacyl-acyl carrier protein synthase I (FabB). RA Hoang TT, Schweizer HP. RL J Bacteriol 1997 Sep;179(17):5326-32 DR HAMAP; MF_00405; 117 of 119
Genome PropertyGenProp0681: fatty acid biosynthesis from acetyl-CoA (HMM)