HMM Summary Page: TIGR01755

FunctionNAD(P)H:quinone oxidoreductase, type IV
Gene SymbolwrbA
Trusted Cutoff132.50
Domain Trusted Cutoff132.50
Noise Cutoff121.15
Domain Noise Cutoff121.15
Isology Typeequivalog
EC Number1.6.5.2
HMM Length197
Mainrole CategoryEnergy metabolism
Subrole CategoryElectron transport
Gene Ontology TermGO:0003955: NAD(P)H dehydrogenase (quinone) activity molecular_function
GO:0055114: oxidation-reduction process biological_process
AuthorHaft DH
Entry DateNov 25 2002 5:02PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a protein, WrbA, related to and slightly larger than flavodoxin. It was just shown, in E. coli and Archaeoglobus fulgidus (and previously for some eukaryotic homologs) to act as fourth type of NAD(P)H:quinone oxidoreductase. In E. coli, this protein was earlier reported to be produced during stationary phase, bind to the trp repressor, and make trp operon repression more efficient. WrbA does not interact with the trp operator by itself. Members are found in species in which homologs of the E. coli trp operon repressor TrpR (SP:P03032) are not detected.
ReferencesRN [1] RM PMID: 16672604 RT WrbA from Escherichia coli and Archaeoglobus fulgidus is an NAD(P)H:quinone oxidoreductase. RA Patridge EV, Ferry JG RL J Bacteriol. 2006 May;188(10):3498-506. RN [2] RM PMID: 9694845 RT Biochemical characterization of WrbA, founding member of a new family of multimeric flavodoxin-like proteins. RA Grandori R, Khalifah P, Boice JA, Fairman R, Giovanielli K, Carey J RL J Biol Chem. 1998 Aug 14;273(33):20960-6. RN [3] RM 8516330 RT A stationary-phase protein of Escherichia coli that affects the mode of association between the trp repressor protein and operator-bearing DNA. RA Yang W, Ni L, Somerville RL RL Proc Natl Acad Sci U S A 1993 Jun 15;90(12):5796-800 DR HAMAP; MF_01017; 83 of 85