HMM Summary Page: TIGR01774

Functionglycyl radical enzyme, PFL2/glycerol dehydratase family
Trusted Cutoff678.20
Domain Trusted Cutoff678.20
Noise Cutoff464.45
Domain Noise Cutoff464.45
Isology Typesubfamily
HMM Length786
AuthorHaft DH, Selengut J
Entry DateDec 20 2002 3:22PM
Last ModifiedAug 31 2011 2:41PM
CommentThis family previously was designated pyruvate formate-lyase, but it now appears that members include the B12-independent glycerol dehydratase. Therefore, the functional definition of the family is being broadened. This family includes the PflF and PflD proteins of E. coli, described as isoforms of pyruvate-formate lyase found in a limited number additional species. PFL catalyzes the reaction pyruvate + CoA -> acetyl-CoA + formate, which is a step in the fermentation of glucose.
Genome PropertyGenProp0943: pyruvate formate-lyase system (HMM)