HMM Summary Page: TIGR01787

AccessionTIGR01787
Namesqualene_cyclas
Functionsqualene/oxidosqualene cyclases
Trusted Cutoff322.70
Domain Trusted Cutoff322.70
Noise Cutoff233.50
Domain Noise Cutoff233.50
Isology Typesubfamily
EC Number5.4.-.-
HMM Length622
AuthorSelengut J
Entry DateJan 6 2003 1:51PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene [1], lanosterol [2], cycloartenol [3], amyrin [4], lupeol and isomultiflorenol [6].
ReferencesRN [1] RM PMID: 12120044 RT Squalene-hopene cyclase: catalytic mechanism and substrate recognition. RA Hoshino T, Sato T. RL Chem Commun (Camb). 2002 Feb 21;(4):291-301. RN [2] RM PMID: 7735243 RT Molecular cloning of cDNA encoding rat 2,3-oxidosqualene: lanosterol cyclase. RA Kusano M, Shibuya M, Sankawa U, Ebizuka Y. RL Biol Pharm Bull 1995 Jan;18(1):195-7 RN [3] RM PMID: 7505443 RT Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen. RA Corey EJ, Matsuda SP, Bartel B. RL Proc Natl Acad Sci U S A 1993 Dec 15;90(24):11628-32 RN [4] RM PMID: 10848960 RT Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase. RA Morita M, Shibuya M, Kushiro T, Masuda K, Ebizuka Y. RL Eur J Biochem 2000 Jun;267(12):3453-60 RN [5] RM PMID: 9883589 RT Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene. RA Herrera JB, Bartel B, Wilson WK, Matsuda SP. RL Phytochemistry 1998 Dec;49(7):1905-11 RN [6] RM PMID: 11733028 RT Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid. RA Hayashi H, Huang P, Inoue K, Hiraoka N, Ikeshiro Y, Yazaki K, Tanaka S, Kushiro T, Shibuya M, Ebizuka Y. RL Eur J Biochem 2001 Dec;268(23):6311-7
Genome PropertyGenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (HMM-CLUST)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (HMM-CLUST)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (HMM-CLUST)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (HMM-CLUST)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (HMM-CLUST)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (HMM-CLUST)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (HMM-CLUST)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (HMM-CLUST)
GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (HMM-CLUST)