HMM Summary Page: TIGR01791

Functionchorismate mutase
Trusted Cutoff66.95
Domain Trusted Cutoff66.95
Noise Cutoff63.75
Domain Noise Cutoff63.75
Isology Typeequivalog_domain
EC Number5.4.99.5
HMM Length83
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAromatic amino acid family
AuthorSelengut J
Entry DateJan 14 2003 5:49PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a clade of archaeal chorismate mutases. Chorismate mutase catalyzes the conversion of chorismate into prephenate which is subsequently converted into either phenylalanine or tyrosine. In Sulfolobus this gene is found as a fusion with prephenate dehydrogenase (although the non-TIGR annotation contains a typographical error indicating it as a dehydratase OMNI|NTL02SS0274) which is the next enzyme in the tyrosine biosynthesis pathway. The Archaeoglobus gene contains an N-terminal prephenate dehydrogenase domain and a C-terminal prephenate dehydratase domain followed by a regulatory amino acid-binding ACT domain. The Thermoplasma volcanium gene is adjacent to prephenate dehydratase.
Genome PropertyGenProp0039: phenylalanine biosynthesis from chorismate (HMM)
GenProp0045: tyrosine biosynthesis from chorismate (HMM)