|Function||2-methylcitrate synthase/citrate synthase II|
|Domain Trusted Cutoff||421.30|
|Domain Noise Cutoff||418.15|
|Entry Date||Jan 22 2003 12:58PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Members of this family are dimeric enzymes with activity as 2-methylcitrate synthase, citrate synthase, or both. Many Gram-negative species have a hexameric citrate synthase, termed citrate synthase I (TIGR01798). Members of this family (TIGR01800) appear as a second citrate synthase isozyme but typically are associated with propionate metabolism and synthesize 2-methylcitrate from propionyl-CoA; citrate synthase activity may be incidental. A number of species, including Thermoplasma acidophilum, Pyrococcus furiosus, and the Antarctic bacterium DS2-3R have a bifunctional member of this family as the only citrate synthase isozyme.|
RT Citrate synthase and 2-methylcitrate synthase: structural, functional and evolutionary relationships.
RA Gerike U, Hough DW, Russell NJ, Dyall-Smith ML, Danson MJ.
RL Microbiology 1998 Apr;144 ( Pt 4):929-35|
|Genome Property||GenProp0033: TCA cycle (HMM)|
| ||GenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM)|
© J. Craig Venter Institute | Privacy Statement | Data Disclaimer