HMM Summary Page: TIGR01836

Functionpoly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit
Gene SymbolphaC
Trusted Cutoff365.30
Domain Trusted Cutoff365.30
Noise Cutoff174.75
Domain Noise Cutoff174.75
Isology Typesubfamily
HMM Length350
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryBiosynthesis
AuthorHaft DH
Entry DateFeb 26 2003 12:15PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the PhaC subunit of a heterodimeric form of polyhydroxyalkanoic acid (PHA) synthase. Excepting the PhaC of Bacillus megaterium (which needs PhaR), all members require PhaE (TIGR01834) for activity and are designated class III. This enzyme builds ester polymers for carbon and energy storage that accumulate in inclusions, and both this enzyme and the depolymerase associate with the inclusions. Class III enzymes polymerize short-chain-length hydroxyalkanoates.
ReferencesRM 11418564 RT PhaC and PhaR are required for polyhydroxyalkanoic acid synthase activity in Bacillus megaterium. RA McCool GJ, Cannon MC. RL J Bacteriol 2001 Jul;183(14):4235-43
Genome PropertyGenProp0055: polyhydroxyalkanoic acids (HMM)