|Function||type I secretion outer membrane protein, TolC family|
|Domain Trusted Cutoff||225.15|
|Domain Noise Cutoff||183.80|
|Mainrole Category||Protein fate|
|Subrole Category||Protein and peptide secretion and trafficking|
|Gene Ontology Term||GO:0006810: transport biological_process|
| ||GO:0009279: cell outer membrane cellular_component|
| ||GO:0015288: porin activity molecular_function|
|Entry Date||Mar 4 2003 4:00PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Members of this HMM are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa).|
RT The role of the TolC family in protein transport and multidrug efflux. From stereochemical certainty to mechanistic hypothesis.
RA Sharff A, Fanutti C, Shi J, Calladine C, Luisi B.
RL Eur J Biochem 2001 Oct;268(19):5011-26|
|Genome Property||GenProp0059: type I secretion (HMM)|
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