HMM Summary Page: TIGR01852

Functionacyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase
Gene SymbollpxA
Trusted Cutoff231.05
Domain Trusted Cutoff231.05
Noise Cutoff114.05
Domain Noise Cutoff114.05
Isology Typeequivalog
EC Number2.3.1.129
HMM Length254
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0008780: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity molecular_function
GO:0009245: lipid A biosynthetic process biological_process
AuthorHaft DH
Entry DateMar 14 2003 10:30AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes LpxA, an enzyme for the biosynthesis of lipid A, a component oflipopolysaccharide (LPS) in the outer membrane outer leaflet of most Gram-negative bacteria. Some differences are found between lipid A of different species, but this protein represents the first step (from UDP-N-acetyl-D-glucosamine) and appears to be conserved in function. Proteins from this family contain many copies of the bacterial transferase hexapeptide repeat (PF00132).
ReferencesDR URL; DR HAMAP; MF_00387; 175 of 177
Genome PropertyGenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM)