HMM Summary Page: TIGR01854

FunctionUDP-2,3-diacylglucosamine diphosphatase
Gene SymbollpxH
Trusted Cutoff190.35
Domain Trusted Cutoff190.35
Noise Cutoff94.55
Domain Noise Cutoff94.55
Isology Typeequivalog
EC Number3.6.1.54
HMM Length231
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0008758: UDP-2,3-diacylglucosamine hydrolase activity molecular_function
GO:0009245: lipid A biosynthetic process biological_process
AuthorHaft DH
Entry DateMar 17 2003 9:07AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents LpxH, UDP-2,3-diacylglucosamine hydrolase, and essential enzyme in E. coli that catalyzes the fourth step in lipid A biosynthesis. Note that Pseudomonas aeruginosa has both a member of this family that shares this function and a more distant homolog, designated LpxH2, that does not. Many species that produce lipid A lack an lpxH gene in this family; some of those species have an lpxH2 gene instead, although for which the function is unknown.
ReferencesRM 12000771 RT Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene. RA Babinski KJ, Kanjilal SJ, Raetz CR. RL J Biol Chem 2002 Jul 19;277(29):25947-56 DR HAMAP; MF_00575; 107 of 110
Genome PropertyGenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM)