|Domain Trusted Cutoff||190.35|
|Domain Noise Cutoff||94.55|
|Mainrole Category||Cell envelope|
|Subrole Category||Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides|
|Gene Ontology Term||GO:0008758: UDP-2,3-diacylglucosamine hydrolase activity molecular_function|
| ||GO:0009245: lipid A biosynthetic process biological_process|
|Entry Date||Mar 17 2003 9:07AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This HMM represents LpxH, UDP-2,3-diacylglucosamine hydrolase, and essential enzyme in E. coli that catalyzes the fourth step in lipid A biosynthesis. Note that Pseudomonas aeruginosa has both a member of this family that shares this function and a more distant homolog, designated LpxH2, that does not. Many species that produce lipid A lack an lpxH gene in this family; some of those species have an lpxH2 gene instead, although for which the function is unknown.|
RT Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene.
RA Babinski KJ, Kanjilal SJ, Raetz CR.
RL J Biol Chem 2002 Jul 19;277(29):25947-56
DR HAMAP; MF_00575; 107 of 110|
|Genome Property||GenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM)|
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