|Function||histidinol phosphate phosphatase, HisJ family|
|Domain Trusted Cutoff||90.20|
|Domain Noise Cutoff||38.60|
|Entry Date||Mar 20 2003 3:59PM|
|Last Modified||May 25 2011 6:48PM|
|Comment||This HMM represents the histidinol phosphate phosphatase HisJ of Bacillus subtilis, and related proteins from a number of species within a larger family of phosphatases in the PHP hydrolase family. HisJ catalyzes the penultimate step of histidine biosynthesis but shows no homology to the functionally equivalent sequence in E. coli, a domain of the bifunctional HisB protein. Note, however, that many species have two members and that Clostridium perfringens, predicted not to make histidine, has five members of this family; this family is designated subfamily rather than equivalog to indicate that members may not all act as HisJ.|
RT Histidinol phosphate phosphatase, catalyzing the penultimate step of the histidine biosynthesis pathway, is encoded by ytvP (hisJ) in Bacillus subtilis.
RA le Coq D, Fillinger S, Aymerich S.
RL J Bacteriol 1999 May;181(10):3277-80|
|Genome Property||GenProp0109: histidine biosynthesis from ribose-5-phosphate (HMM)|
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