HMM Summary Page: TIGR01857

AccessionTIGR01857
NameFGAM-synthase
Functionphosphoribosylformylglycinamidine synthase
Trusted Cutoff1057.05
Domain Trusted Cutoff1057.05
Noise Cutoff797.80
Domain Noise Cutoff797.80
Isology Typeequivalog
EC Number6.3.5.3
HMM Length1239
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPurine ribonucleotide biosynthesis
Gene Ontology TermGO:0004642: phosphoribosylformylglycinamidine synthase activity molecular_function
GO:0004642: phosphoribosylformylglycinamidine synthase activity molecular_function
GO:0006189: 'de novo' IMP biosynthetic process biological_process
GO:0006189: 'de novo' IMP biosynthetic process biological_process
AuthorSelengut J
Entry DateMar 21 2003 5:15PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP.
Genome PropertyGenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)
GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)
GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)
GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)
GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)
GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)