HMM Summary Page: TIGR01920

Functionshikimate kinase
Trusted Cutoff126.85
Domain Trusted Cutoff126.85
Noise Cutoff124.45
Domain Noise Cutoff124.45
Isology Typeequivalog
EC Number2.7.1.71
HMM Length266
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAromatic amino acid family
Gene Ontology TermGO:0004765: shikimate kinase activity molecular_function
GO:0009423: chorismate biosynthetic process biological_process
AuthorSelengut J
Entry DateJun 30 2003 12:38PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the shikimate kinase (SK) gene found in archaea which is only distantly related to homoserine kinase (thrB) and not atr all to the bacterial SK enzyme. The SK from M. janaschii has been overexpressed in E. coli and characterized [1]. SK catalyzes the fifth step of the biosynthesis of chorismate from D-erythrose-4-phosphate and phosphoenolpyruvate.
ReferencesRN [1] RM PMID: 11114929 RT Archaeal shikimate kinase, a new member of the GHMP-kinase family. RA Daugherty M, Vonstein V, Overbeek R, Osterman A. RL J Bacteriol. 2001 Jan;183(1):292-300. DR HAMAP; MF_00370; 19 of 19
Genome PropertyGenProp0001: chorismate biosynthesis via shikimate (HMM)