|Function||anti-sigma B factor|
|Domain Trusted Cutoff||155.05|
|Domain Noise Cutoff||100.10|
|Author||Nelson WE, Selengut J|
|Entry Date||Jul 11 2003 5:31PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This model describes the anti-sigma B factor also known as serine-protein kinase RsbW. Sigma B controls the general stress regulon in B subtilis and is activated by cell stresses such as stationary phase and heat shock. RsbW binds to sigma B and prevents formation of the transcription complex at the promoter. RsbV (anti-anti-sigma factor) binds to RsbW to inhibit association with sigma B, however RsbW can phosphorylate RsbV, causing disassociation of the RsbV/RsbW complex. Low ATP level or environmental stress causes the dephosphorylation of RsbV.|
RM PMID: 8460143
RT Bacillus subtilis sigma B is regulated by a binding protein (RsbW) that blocks its association with core RNA polymerase.
RA Benson AK, Haldenwang WG.
RL Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2330-4.
RM PMID: 8144446
RT Interactions between a Bacillus subtilis anti-sigma factor (RsbW) and its antagonist (RsbV).
RA Dufour A, Haldenwang WG.
RL J Bacteriol. 1994 Apr;176(7):1813-20.
RM PMID: 8808936
RT Reactivation of the Bacillus subtilis anti-sigma B antagonist, RsbV, by stress- or starvation-induced phosphatase activities.
RA Voelker U, Voelker A, Haldenwang WG.
RL J Bacteriol. 1996 Sep;178(18):5456-63.
DR HAMAP; MF_00638; 35 of 35|
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