|Function||anti-sigma F factor|
|Domain Trusted Cutoff||91.75|
|Domain Noise Cutoff||78.90|
|Mainrole Category||Regulatory functions|
|Subrole Category||Protein interactions|
|Gene Ontology Term||GO:0004672: protein kinase activity molecular_function|
| ||GO:0030436: asexual sporulation biological_process|
|Entry Date||Jul 15 2003 9:40AM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter. SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex. The SpoIIE phosphatase dephosphorylates SpoIIAA.|
RT SpoIIAB is an anti-sigma factor that binds to and inhibits transcription by regulatory protein sigma F from Bacillus subtilis.
RA Duncan L, Losick R.
RL Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2325-9.
RT Sigma F, the first compartment-specific transcription factor of B. subtilis, is regulated by an anti-sigma factor that is also a protein kinase.
RA Min KT, Hilditch CM, Diederich B, Errington J, Yudkin MD.
RL Cell. 1993 Aug 27;74(4):735-42.
DR HAMAP; MF_00637; 29 of 29|
|Genome Property||GenProp0610: endospore formation marker gene set (HMM)|
© J. Craig Venter Institute | Privacy Statement | Data Disclaimer