HMM Summary Page: TIGR01929

Functionnaphthoate synthase
Gene SymbolmenB
Trusted Cutoff342.70
Domain Trusted Cutoff342.70
Noise Cutoff201.40
Domain Noise Cutoff201.40
Isology Typeequivalog
EC Number4.1.3.36
HMM Length259
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0008935: 1,4-dihydroxy-2-naphthoyl-CoA synthase activity molecular_function
GO:0009234: menaquinone biosynthetic process biological_process
AuthorSunshine J
Entry DateJul 17 2003 9:45AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents an enzyme, naphthoate synthase (dihydroxynaphthoic acid synthetase), which is involved in the fifth step of the menaquinone biosynthesis pathway. Together with o-succinylbenzoate-CoA ligase (menE: TIGR01923), this enzyme takes 2-succinylbenzoate and converts it into 1,4-di-hydroxy-2-naphthoate. Included above the trusted cutoff are two enzymes from Arabadopsis thaliana and one from Staphylococcus aureus which are identified as putative enoyl-CoA hydratase/isomerases. These enzymes group with the naphthoate synthases when building a tree and when doing BLAST searches.
Genome PropertyGenProp0058: menaquinone biosynthesis via SEPHCHC (HMM)