|Function||ubiquinone/menaquinone biosynthesis methyltransferase|
|Domain Trusted Cutoff||158.35|
|Domain Noise Cutoff||112.50|
|Gene Ontology Term||GO:0008168: methyltransferase activity molecular_function|
| ||GO:0008299: isoprenoid biosynthetic process biological_process|
|Entry Date||Jul 22 2003 4:23PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli  are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (PF01209) which also contains ubiquinone methyltransferases and other methyltransferases.
Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 220.127.116.11) from Rhodobacter sphaeroides .
Note that a number of non-orthologous genes which are members of PF03737 have been erroneously annotated as MenG methyltransferases.|
RM PMID: 9045837
RT A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene.
RA Lee PT, Hsu AY, Ha HT, Clarke CF.
RL J Bacteriol. 1997 Mar;179(5):1748-54.
RM PMID: 8340421
RT Isolation and functional expression in Escherichia coli of a gene encoding phosphatidylethanolamine methyltransferase (EC 18.104.22.168) from Rhodobacter sphaeroides.
RA Arondel V, Benning C, Somerville CR.
RL J Biol Chem. 1993 Jul 25;268(21):16002-8.
DR HAMAP; MF_01813; 269 of 275|
|Genome Property||GenProp0058: menaquinone biosynthesis via SEPHCHC (HMM)|
| ||GenProp0136: ubiquinone biosynthesis from chorismate, aerobic (HMM)|
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