HMM Summary Page: TIGR01953

Functiontranscription termination factor NusA
Gene SymbolnusA
Trusted Cutoff253.40
Domain Trusted Cutoff253.40
Noise Cutoff169.10
Domain Noise Cutoff169.10
Isology Typeequivalog_domain
HMM Length340
Mainrole CategoryTranscription
Subrole CategoryTranscription factors
Gene Ontology TermGO:0003715: transcription termination factor activity molecular_function
GO:0006353: transcription termination, DNA-dependent biological_process
AuthorHaft DH
Entry DateJul 28 2003 10:13AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes NusA, or N utilization substance protein A, a bacterial transcription termination factor. It binds to RNA polymerase alpha subunit and promotes termination at certain RNA hairpin structures. It is named for the interaction in E. coli of phage lambda antitermination protein N with the N-utilization substance, consisting of NusA, NusB, NusE (ribosomal protein S10), and nusG. This model represents a region of NusA shared in all bacterial forms, and including an S1 (PF00575) and a KH (PF00013) RNA binding domains. Proteobacterial forms have an additional C-terminal region, not included in this model, with two repeats of 50-residue domain rich in acidic amino acids.
ReferencesRN [1] RM 11040219 RT The alpha subunit of E. coli RNA polymerase activates RNA binding by NusA. RA Mah TF, Kuznedelov K, Mushegian A, Severinov K, Greenblatt J. RL Genes Dev. 2000 Oct 15;14(20):2664-75
Genome PropertyGenProp0132: transcription termination - antitermination Nus factors (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)