Accession | TIGR01967 |
Name | DEAH_box_HrpA |
Function | RNA helicase HrpA |
Gene Symbol | hrpA |
Trusted Cutoff | 722.75 |
Domain Trusted Cutoff | 722.75 |
Noise Cutoff | 558.45 |
Domain Noise Cutoff | 558.45 |
Isology Type | equivalog |
EC Number | 3.6.4.13 |
HMM Length | 1284 |
Mainrole Category | Unknown function |
Subrole Category | Enzymes of unknown specificity |
Gene Ontology Term | GO:0006139: nucleobase-containing compound metabolic process biological_process |
| GO:0008026: ATP-dependent helicase activity molecular_function |
Author | Haft DH |
Entry Date | Aug 29 2003 3:54PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. |
References | RN [1]
RM PMID:15186427
RT HrpA, a DEAH-box RNA helicase, is involved in mRNA processing of a fimbrial operon in Escherichia coli.
RA Koo JT, Choe J, Moseley SL
RL Mol Microbiol. 2004 Jun;52(6):1813-26.
RN [2]
RM PMID:24367266
RT HrpA, an RNA Helicase Involved in RNA Processing, Is Required for Mouse Infectivity and Tick Transmission of the Lyme Disease Spirochete.
RA Salman-Dilgimen A, Hardy PO, Radolf JD, Caimano MJ, Chaconas G
RL PLoS Pathog. 2013 Dec;9(12):e1003841. |