HMM Summary Page: TIGR02022

Functionformiminoglutamate deiminase
Gene SymbolhutF
Trusted Cutoff413.05
Domain Trusted Cutoff413.05
Noise Cutoff213.90
Domain Noise Cutoff213.90
Isology Typeequivalog
EC Number3.5.3.13
HMM Length455
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0019557: histidine catabolic process to glutamate and formate biological_process
GO:0050416: formimidoylglutamate deiminase activity molecular_function
AuthorHaft DH
Entry DateOct 15 2003 2:57PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn some species, histidine utilization goes via urocanate to glutamate in four step, the last being removal of formamide. This HMM describes an alternate fourth step, formiminoglutamate hydrolase, which leads to N-formyl-L-glutamate. This product may be acted on by formylglutamate amidohydrolase (TIGR02017) and bypass glutamate as a product during its degradation. Alternatively, removal of formate (by EC would yield glutamate.
ReferencesRM 2842309 RT Organization and multiple regulation of histidine utilization genes in Pseudomonas putida. RA Hu L, Phillips AT. RL J Bacteriol. 1988 Sep;170(9):4272-9.
Genome PropertyGenProp0145: histidine degradation to glutamate (HMM)