HMM Summary Page: TIGR02027

FunctionDNA-directed RNA polymerase, alpha subunit
Gene SymbolrpoA
Trusted Cutoff227.80
Domain Trusted Cutoff227.80
Noise Cutoff112.40
Domain Noise Cutoff112.40
Isology Typeequivalog
EC Number2.7.7.6
HMM Length298
Mainrole CategoryTranscription
Subrole CategoryDNA-dependent RNA polymerase
Gene Ontology TermGO:0000345: cytosolic DNA-directed RNA polymerase complex cellular_component
GO:0003899: DNA-directed RNA polymerase activity molecular_function
GO:0006350: transcription biological_process
AuthorHaft DH, Dodson RJ
Entry DateOct 17 2003 1:43PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of the bacterial (and chloroplast) DNA-directed RNA polymerase alpha subunit, encoded by the rpoA gene. The RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The amino terminal domain is involved in dimerizing and assembling the other RNA polymerase subunits into a transcriptionally active enzyme. The carboxy-terminal domain contains determinants for interaction with DNA and with transcriptional activator proteins.
ReferencesRN [1] RM 9657722 RT Structure of the Escherichia coli RNA polymerase alpha subunit amino-terminal domain. RA Zhang G, Darst SA. RL Science. 1998 Jul 10;281(5374):262-6. RN [2] RM 7613089 RT The Escherichia coli RNA polymerase alpha subunit: structure and function. RA Ebright RH, Busby S. RL Curr Opin Genet Dev. 1995 Apr;5(2):197-203. DR HAMAP; MF_00059; 671 of 673
Genome PropertyGenProp0262: RNA polymerase, bacterial (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)