Accession | TIGR02038 |
Name | protease_degS |
Function | periplasmic serine peptidase DegS |
Gene Symbol | degS |
Trusted Cutoff | 422.95 |
Domain Trusted Cutoff | 422.95 |
Noise Cutoff | 291.85 |
Domain Noise Cutoff | 291.85 |
Isology Type | equivalog |
EC Number | 3.4.21.- |
HMM Length | 351 |
Mainrole Category | Protein fate |
Subrole Category | Degradation of proteins, peptides, and glycopeptides |
Gene Ontology Term | GO:0008236: serine-type peptidase activity molecular_function |
| GO:0030288: outer membrane-bounded periplasmic space cellular_component |
| GO:0045152: antisigma factor binding molecular_function |
Author | Haft DH |
Entry Date | Oct 24 2003 3:03PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This family consists of the periplasmic serine protease DegS (HhoB), a shorter paralog of protease DO (HtrA, DegP) and DegQ (HhoA). It is found in E. coli and several other Proteobacteria of the gamma subdivision. It contains a trypsin domain and a single copy of PDZ domain (in contrast to DegP with two copies). A critical role of this DegS is to sense stress in the periplasm and partially degrade an inhibitor of sigma(E). |
References | RN [1]
RM 11442831
RT degS (hhoB) is an essential Escherichia coli gene whose indispensable function is to provide sigma (E) activity.
RA Alba BM, Zhong HJ, Pelayo JC, Gross CA.
RL Mol Microbiol. 2001 Jun;40(6):1323-33.
RN [2]
RM 12679025
RT A stress sensor for the bacterial periplasm.
RA Young JC, Hartl FU.
RL Cell. 2003 Apr 4;113(1):1-2. |