| Accession | TIGR02044 |
| Name | CueR |
| Function | Cu(I)-responsive transcriptional regulator |
| Gene Symbol | cueR |
| Trusted Cutoff | 147.40 |
| Domain Trusted Cutoff | 147.40 |
| Noise Cutoff | 116.90 |
| Domain Noise Cutoff | 116.90 |
| Isology Type | equivalog |
| HMM Length | 127 |
| Mainrole Category | Regulatory functions |
| Subrole Category | DNA interactions |
| Gene Ontology Term | GO:0003700: sequence-specific DNA binding transcription factor activity molecular_function |
| | GO:0006355: regulation of transcription, DNA-dependent biological_process |
| | GO:0006878: cellular copper ion homeostasis biological_process |
| | GO:0046688: response to copper ion biological_process |
| Author | Selengut J |
| Entry Date | Nov 3 2003 3:49PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents the copper-, silver- and gold- (I) responsive transcriptional activator of the gamma proteobacterial copper efflux system [1]. This protein is a member of the MerR family of transcriptional activators (PF00376) and contains a distinctive pattern of cysteine residues in its metal binding loop, Cys-X7-Cys. This family also lacks a conserved cysteine at the N-terminal end of the dimerization helix which is required for the binding of divalent metals such as zinc; here it is replaced by a serine residue [2]. |
| References | RN [1]
RM PMID: 11136469
RT CueR (YbbI) of Escherichia coli is a MerR family regulator controlling expression of the copper exporter CopA.
RA Stoyanov JV, Hobman JL, Brown NL.
RL Mol Microbiol. 2001 Jan;39(2):502-11.
RN [2]
RM PMID: 12958362
RT Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR.
RA Changela A, Chen K, Xue Y, Holschen J, Outten CE, O'Halloran TV, Mondragon A.
RL Science. 2003 Sep 5;301(5638):1383-7. |
