|Domain Trusted Cutoff||293.90|
|Domain Noise Cutoff||206.50|
|Mainrole Category||Biosynthesis of cofactors, prosthetic groups, and carriers|
|Subrole Category||Glutathione and analogs|
|Gene Ontology Term||GO:0004357: glutamate-cysteine ligase activity molecular_function|
| ||GO:0006750: glutathione biosynthetic process biological_process|
|Entry Date||Nov 6 2003 3:48PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This family consists of a rare family of glutamate--cysteine ligases, demonstrated first in Thiobacillus ferrooxidans and present in a few other Proteobacteria. It is the first of two enzymes for glutathione biosynthesis. It is also called gamma-glutamylcysteine synthetase.|
RT The gene for gamma-glutamylcysteine synthetase from Thiobacillus ferrooxidans has low homology to its Escherichia coli equivalent and is linked to the gene for citrate synthase.
RA Powles R, Deane S, Rawlings D.
RL Microbiology. 1996 Sep;142 ( Pt 9):2543-8.|
|Genome Property||GenProp0030: glutathione biosynthesis (HMM)|
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