HMM Summary Page: TIGR02052

Functionmercuric transport protein periplasmic component
Gene SymbolmerP
Trusted Cutoff92.55
Domain Trusted Cutoff92.55
Noise Cutoff65.20
Domain Noise Cutoff65.20
Isology Typeequivalog
HMM Length92
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0015694: mercury ion transport biological_process
GO:0045340: mercury ion binding molecular_function
AuthorSelengut J
Entry DateNov 7 2003 1:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the periplasmic mercury (II) binding protein of the bacterial mercury detoxification system which passes mercuric ion to the MerT transporter for subsequent reduction to Hg(0) by the mercuric reductase MerA. MerP contains a distinctive GMTCXXC motif associated with metal binding [1]. MerP is related to a larger family of metal binding proteins (PF00403).
ReferencesRN [1] RM PMID: 9188683 RT Structures of the reduced and mercury-bound forms of MerP, the periplasmic protein from the bacterial mercury detoxification system. RA Steele RA, Opella SJ. RL Biochemistry. 1997 Jun 10;36(23):6885-95.
Genome PropertyGenProp0151: resistance to mercury (HMM)