HMM Summary Page: TIGR02054

Functionmercuric resistence transcriptional repressor protein MerD
Gene SymbolmerD
Trusted Cutoff103.65
Domain Trusted Cutoff103.65
Noise Cutoff69.95
Domain Noise Cutoff69.95
Isology Typeequivalog
HMM Length120
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0016564: transcription repressor activity molecular_function
GO:0046689: response to mercury ion biological_process
AuthorSelengut J
Entry DateNov 7 2003 4:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a transcriptional repressor protein of the MerR family (PF00376) whose expression is regulated by the mercury-sensitive transcriptional activator, MerR. MerD has been shown to repress the transcription of the mer operon [1].
ReferencesRN [1] RM PMID: 1917975 RT Purification and functional characterization of MerD. A coregulator of the mercury resistance operon in gram-negative bacteria. RA Mukhopadhyay D, Yu HR, Nucifora G, Misra TK. RL J Biol Chem. 1991 Oct 5;266(28):18538-42.
Genome PropertyGenProp0151: resistance to mercury (HMM)