HMM Summary Page: TIGR02061

AccessionTIGR02061
NameaprA
Functionadenylylsulfate reductase, alpha subunit
Gene SymbolaprA
Trusted Cutoff641.75
Domain Trusted Cutoff641.75
Noise Cutoff326.00
Domain Noise Cutoff326.00
Isology Typeequivalog
EC Number1.8.99.2
HMM Length616
Mainrole CategoryCentral intermediary metabolism
Subrole CategorySulfur metabolism
Gene Ontology TermGO:0009973: adenylyl-sulfate reductase activity molecular_function
GO:0009973: adenylyl-sulfate reductase activity molecular_function
GO:0019420: dissimilatory sulfate reduction biological_process
GO:0019420: dissimilatory sulfate reduction biological_process
GO:0019425: sulfur oxidation, using siroheme sulfite reductase biological_process
GO:0019425: sulfur oxidation, using siroheme sulfite reductase biological_process
AuthorBrinkac L
Entry DateNov 24 2003 3:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentDuring dissimilatory sulfate reduction or sulfur oxidation, adenylylsulfate (APS) reductase catalyzes reversibly the two-electron reduction of APS to sulfite and AMP [1]. Found in several bacterial lineages and in Archaeoglobales, APS reductase is a heterodimer composed of an alpha subunit containing a noncovalently bound FAD, and a beta subunit containing two [4Fe-4S] clusters [1]. Described by this model is the alpha subunit of APS reductase, sharing common evolutionary origin with fumarate reductase/succinate dehydrogenase flavoproteins.
ReferencesRN [1] RM 10802060 RT Adenylylsulfate reductases from archaea and bacteria are 1:1 alphabeta-heterodimeric iron-sulfur flavoenzymes--high similarity of molecular properties emphasizes their central role in sulfur metabolism. RA Fritz G, Buchert T, Huber H, Stetter KO, Kroneck PM. RL FEBS Lett. 2000 May 4;473(1):63-6. DR PFAM; PF02910; Fumarate reductase/succinate dehydrogenase flavoprotein C-terminal domain DR PFAM; PF00890; FAD binding domain DR EXPERIMENTAL; GP|2576391; Allochromatium vinosum; insertional inactivation resulted in inability to synthesize APS from sulfite and AMP. DR EXPERIMENTAL; GP|2648887; Archaeoglobus fulgidus; purified by chromatography, with APS reductase activity measured by spectroscopy. DR OUTGROUP; GP|2649111; Archaeoglobus fulgidus DSM4304; fumarate reductase, flavoprotein subunit.
Genome PropertyGenProp0155: dissimilatory sulfate reduction (HMM)
GenProp0155: dissimilatory sulfate reduction (HMM)