HMM Summary Page: TIGR02067

Gene SymbolhisN
Trusted Cutoff275.15
Domain Trusted Cutoff275.15
Noise Cutoff190.95
Domain Noise Cutoff190.95
Isology Typeequivalog
EC Number3.1.3.15
HMM Length252
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryHistidine family
Gene Ontology TermGO:0000105: histidine biosynthetic process biological_process
GO:0004401: histidinol-phosphatase activity molecular_function
AuthorHaft DH
Entry DateNov 26 2003 2:53PM
Last ModifiedSep 2 2011 2:20PM
CommentThis subfamily belongs to the inositol monophosphatase family (PF00459). The members of this family consist of no more than one per species and are found only in species in which histidine is synthesized de novo but no histidinol phosphatase can be found in either of the two described families (TIGR01261, TIGR01856). In at least one species, the member of this family is found near known histidine biosynthesis genes. The role as histidinol-phosphatase wsa first proven in Corynebacterium glutamicum.
ReferencesDR PFAM; PF00459; inositol monophosphatase family RN [1] RM PMID: 15347579 RT Genome Properties: a system for the investigation of prokaryotic genetic content for microbiology, genome annotation and comparative genomics. RA Haft DH, Selengut JD, Brinkac LM, Zafar N, White O RL Bioinformatics. 2005 Feb 1;21(3):293-306. RN [2] RM PMID: 16901339 RT Random mutagenesis in Corynebacterium glutamicum ATCC 13032 using an IS6100-based transposon vector identified the last unknown gene in the histidine biosynthesis pathway. RA Mormann S, Lomker A, Ruckert C, Gaigalat L, Tauch A, Puhler A, Kalinowski J RL BMC Genomics. 2006 Aug 10;7:205.
Genome PropertyGenProp0109: histidine biosynthesis from ribose-5-phosphate (HMM)