HMM Summary Page: TIGR02072

Functionmalonyl-acyl carrier protein O-methyltransferase BioC
Gene SymbolbioC
Trusted Cutoff184.95
Domain Trusted Cutoff184.95
Noise Cutoff134.85
Domain Noise Cutoff134.85
Isology Typeequivalog
EC Number2.1.1.-
HMM Length244
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryBiotin
Gene Ontology TermGO:0009102: biotin biosynthetic process biological_process
AuthorSelengut J, Haft DH
Entry DateDec 10 2003 4:27PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology.
ReferencesRN [1] RM PMID:22965231 RT The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis. RA Lin S, Cronan JE RL J Biol Chem. 2012 Oct 26;287(44):37010-20.
Genome PropertyGenProp0036: biotin biosynthesis (HMM)