| Accession | TIGR02082 |
| Name | metH |
| Function | methionine synthase |
| Gene Symbol | metH |
| Trusted Cutoff | 1010.85 |
| Domain Trusted Cutoff | 1010.85 |
| Noise Cutoff | 486.10 |
| Domain Noise Cutoff | 486.10 |
| Isology Type | equivalog |
| EC Number | 2.1.1.13 |
| HMM Length | 1182 |
| Mainrole Category | Amino acid biosynthesis |
| Subrole Category | Aspartate family |
| Gene Ontology Term | GO:0008705: methionine synthase activity molecular_function |
| | GO:0009086: methionine biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Dec 23 2003 11:23AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family represents 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13), one of at least three different enzymes able to convert homocysteine to methionine by transferring a methyl group on to the sulfur atom. It is also called the vitamin B12(or cobalamine)-dependent methionine synthase. Other methionine synthases include 5-methyltetrahydropteroyltriglutamate--homocysteine
S-methyltransferase (MetE, EC 2.1.1.14, the cobalamin-independent methionine synthase) and betaine-homocysteine methyltransferase. |
| References | DR EXPERIMENTAL; SP|P13009; Escherichia coli
DR EXPERIMENTAL; SP|Q99707; Homo sapiens |
| Genome Property | GenProp0161: methionine biosynthesis from homoserine (HMM) |
| | GenProp0284: cobalamin-utilizing enzymes (HMM) |
