HMM Summary Page: TIGR02084

Function3-isopropylmalate dehydratase, small subunit
Gene SymbolleuD
Trusted Cutoff245.85
Domain Trusted Cutoff245.85
Noise Cutoff231.40
Domain Noise Cutoff231.40
Isology Typeequivalog
EC Number4.2.1.33
HMM Length156
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryPyruvate family
Gene Ontology TermGO:0003861: 3-isopropylmalate dehydratase activity molecular_function
GO:0009098: leucine biosynthetic process biological_process
GO:0009316: 3-isopropylmalate dehydratase complex cellular_component
AuthorSelengut J
Entry DateDec 23 2003 4:47PM
Last ModifiedFeb 14 2011 3:27PM
CommentHomoaconitase, aconitase, and 3-isopropylmalate dehydratase have similar overall structures. All are dehydratases (EC 4.2.1.-) and bind a Fe-4S iron-sulfur cluster. 3-isopropylmalate dehydratase is split into large (leuC) and small (leuD) chains in eubacteria. Several pairs of archaeal proteins resemble the leuC and leuD pair in length and sequence but even more closely resemble the respective domains of homoaconitase, and their identity is uncertain. The members of the seed for this model are those sequences which are gene clustered with other genes involved in leucine biosynthesis and include some archaea.
References DR HAMAP; MF_01032; 9 of 44
Genome PropertyGenProp0164: leucine biosynthesis from pyruvate and acetyl-CoA (HMM)