HMM Summary Page: TIGR02113

Functionphosphopantothenoylcysteine decarboxylase
Gene SymbolcoaC
Trusted Cutoff261.40
Domain Trusted Cutoff261.40
Noise Cutoff213.20
Domain Noise Cutoff213.20
Isology Typeequivalog
EC Number4.1.1.36
HMM Length177
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPantothenate and coenzyme A
Gene Ontology TermGO:0004633: phosphopantothenoylcysteine decarboxylase activity molecular_function
GO:0015937: coenzyme A biosynthetic process biological_process
AuthorHaft DH
Entry DateJan 27 2004 9:03AM
Last ModifiedFeb 14 2011 3:27PM
CommentIn most bacteria, a single bifunctional protein catalyses phosphopantothenoylcysteine decarboxylase and phosphopantothenate--cysteine ligase activities, sequential steps in coenzyme A biosynthesis (see TIGR00521). These activities reside in separate proteins encoded by tandem genes in some bacterial lineages. This model describes proteins from the genera Streptococcus and Enterococcus homologous to the N-terminal region of TIGR00521, corresponding to phosphopantothenoylcysteine decarboxylase activity.
ReferencesRM 11278255 RT Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria. RA Strauss E, Kinsland C, Ge Y, McLafferty FW, Begley TP. RL J Biol Chem. 2001 Apr 27; 276(17): 13513-6.
Genome PropertyGenProp0171: coenzyme A biosynthesis from pantothenate (HMM)