HMM Summary Page: TIGR02116

Functionaddiction module toxin, Txe/YoeB family
Trusted Cutoff51.80
Domain Trusted Cutoff51.80
Noise Cutoff41.60
Domain Noise Cutoff41.60
Isology Typeequivalog
HMM Length80
Mainrole CategoryCellular processes
Subrole CategoryToxin production and resistance
Gene Ontology TermGO:0008219: cell death biological_process
AuthorHaft DH
Entry DateJan 29 2004 3:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Axe-Txe pair in Enterococcus faecium and the homologous YefM-YoeB pair in Escherichia coli have been shown to act as an antitoxin-toxin pair. This HMM describes the toxin component. Nearly every example found is next to an identifiable antitoxin, as indicated by match to HMMs TIGR01552 and/or PF02604.
ReferencesRM 12603745 RT Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium. RA Grady R, Hayes F. RL Mol Microbiol. 2003 Mar; 47(5): 1419-32.
Genome PropertyGenProp0321: toxin-antitoxin system, type II (HMM)