|Domain Trusted Cutoff||413.55|
|Domain Noise Cutoff||400.45|
|Entry Date||Mar 11 2004 4:33PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This model includes the yeast LYS21 gene which carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. A related pathway is found in Thermus thermophilus . This enzyme is closely related to 2-isopropylmalate synthase (LeuA) and citramalate synthase (CimA), both of which are present in the euryarchaeota. Some archaea have a separate homocitrate synthase (AksA) which also synthesizes longer homocitrate analogs .|
RM PMID: 10613839
RT A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis
RA Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H
RL Genome Res. 1999 Dec;9(12):1175-83
RM PMID: 9665716
RT Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea.
RA Howell DM, Harich K, Xu H, White RH.
RL Biochemistry. 1998 Jul 14;37(28):10108-17.
DR HAMAP; MF_01025; 4 of 96|
|Genome Property||GenProp0193: lysine biosynthesis via alpha-aminoadipate (AAA pathway) (HMM)|
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