HMM Summary Page: TIGR02146
Accession | TIGR02146 |
Name | LysS_fung_arch |
Function | homocitrate synthase |
Gene Symbol | lysS |
Trusted Cutoff | 413.55 |
Domain Trusted Cutoff | 413.55 |
Noise Cutoff | 400.45 |
Domain Noise Cutoff | 400.45 |
Isology Type | hypoth_equivalog |
EC Number | 2.3.3.14 |
HMM Length | 344 |
Author | Selengut J |
Entry Date | Mar 11 2004 4:33PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This model includes the yeast LYS21 gene which carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. A related pathway is found in Thermus thermophilus [1]. This enzyme is closely related to 2-isopropylmalate synthase (LeuA) and citramalate synthase (CimA), both of which are present in the euryarchaeota. Some archaea have a separate homocitrate synthase (AksA) which also synthesizes longer homocitrate analogs [2]. |
References | RN [1] RM PMID: 10613839 RT A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis RA Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H RL Genome Res. 1999 Dec;9(12):1175-83 RN [2] RM PMID: 9665716 RT Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea. RA Howell DM, Harich K, Xu H, White RH. RL Biochemistry. 1998 Jul 14;37(28):10108-17. DR HAMAP; MF_01025; 4 of 96 |
Genome Property | GenProp0193: lysine biosynthesis via alpha-aminoadipate (AAA pathway) (HMM) |