HMM Summary Page: TIGR02168

Functionchromosome segregation protein SMC
Gene Symbolsmc
Trusted Cutoff567.35
Domain Trusted Cutoff567.35
Noise Cutoff557.95
Domain Noise Cutoff557.95
Isology Typeequivalog
HMM Length1181
Mainrole CategoryCellular processes
Subrole CategoryCell division
Gene Ontology TermGO:0005524: ATP binding molecular_function
GO:0007059: chromosome segregation biological_process
GO:0030261: chromosome condensation biological_process
AuthorHaft DH
Entry DateApr 22 2004 10:07AM
Last ModifiedFeb 14 2011 3:27PM
CommentSMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle.
ReferencesRN [1] RM 12730166 RT Cell-cycle-regulated expression and subcellular localization of the Caulobacter crescentus SMC chromosome structural protein. RA Jensen RB, Shapiro L. RL J Bacteriol. 2003 May;185(10):3068-75. RN [2] RM 12100548 RT Discovery of two novel families of proteins that are proposed to interact with prokaryotic SMC proteins, and characterization of the Bacillus subtilis family members ScpA and ScpB. RL Mol Microbiol. 2002 Jul;45(1):59-71. RA Soppa J, Kobayashi K, Noirot-Gros MF, Oesterhelt D, Ehrlich SD, Dervyn E, Ogasawara N, Moriya S. RN [3] RM 12411491 RT Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA. RA Hirano M, Hirano T. RL EMBO J. 2002 Nov 1;21(21):5733-44.
Genome PropertyGenProp0201: SMC-ScpA-ScpB complex (HMM)